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O ^ October 1, 1978 through September 30, 1979 PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH SUMMARY ANNUAL REPORT OF PROGRAM ACTIVITIES CLINICAL CENTER OFFICE OF THE DIRECTOR CONTENTS General OD-1 Mission of the Clinical Center OD-1 ACRF and Clinical Center Modernization OD-1 New Services OD-2 Office of the Assistant for Bioethics to the Director, CC OD-3 Medical Board OD-3 Safety OD-5 Office of the Associate Director OD-5 Research Accomplishments OD-9 EEO OD-1 1 Office of Clinical and Management Systems OD-1 2 Office of Clinical Reports and Inquiries OD-1 7 Professional Activities OD-32 Bibl iography OD-32 Normal Vol unteer Program OD-34 Patient Acti vi ty Section OD-44 Anesthesiology Department .. MISSION AND GOAL The primary mission of the Clinical Center Pharmacy Department is to provide comprehensive, properly coordinated pharmaceutical services of the highest quality to the patients and staff of the Clinical Center.OD-57 Critical Care Medicine Department OD-73 n f M B O £.0 October 1, 1978 through September 30, 1979 PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH SUMMARY ANNUAL REPORT OF PROGRAM ACTIVITIES CLINICAL CENTER OFFICE OF THE DIRECTOR General The Clinical Center has continued to evolve both professionally and physically. The Department's goal is to meet the needs of the diagnostic and therapeutic departments, the nursing service, the medical staff, and the hospital as a whole to ensure better patient care.New Services The Critical Care Medicine Department, which was established in 1977 to care for critically ill patients throughout the Clinical Center, took a major step forward in providing services when it opened the doors to its new medical intensive care unit April 30. As a result of several new NCI protocols involving the administrat Lon of cancer chemotherapeutic agents in peritoneal dialysis solutions, the IVAU became involved in the preparation of these solutions.The five bed unit is highly automated to facilitate continuous monitoring and supervision of critically ill patients. Byron Mc Lees has been named Chief of the Critical Care Medicine Department. Cooperating Units: NIAID, NHLBI Man Years: Total: 3.5 Professional: 0.5 Other: 3 I Project Description Objectives : 1. Also, studies were performed by the Pharmaceutical Development Service to assure the compati- bility and stability of these chemotherapeutic agents in the dialysate solutions.Renovations have begun to integrate the Clinical Center with the Ambulatory Care Research Facility and to modernize the hospital. To accomplish its mission and goal, the Pharmacy Department is also engaged in pharmaceutical development, training, and research.Professional services provided by the Clinical Center have been increased despite unchanging personnel ceilings. The Pharmacy Department consists of the Pharmacy, Pharmaceutical Development, Central Sterile Supply Services and the Office of the Chief.

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Clinical Center staff provided hospital services and, for the first time, direct physician care on a limited basis in its new medical intensive care unit. This Service fulfills these responsibilities by dispensing unit doses (individual- ly packaged and labeled dispensing doses) to each patient; it fills drug orders for patients on pass, discharged, and outpatients.Mission of the Clinical Center (1) To ensure the highest possible level of medical care to each patient; (2) To provide optimal resources and facilities for clinical research; (3) To perform research on methods and systems involved in patient care and study; (4) To disseminate information to professionals and to the public relevant to clinical investigation; (5) To develop and maintain training programs in the techniques and ethics of biomedical research and clinical research; (6) To interact with scientists and physicians, nationally and internationally, on mutual problems of clinical research, such as policy, education, ethics, and priorities. and Mac Lowry, J.: Effect of ascorbic acid on detection of blood in urine. The Pharmaceutical Development Service (PDS) is responsible for the registra- tion and control of all investigational drugs used for patients in the Clinical Center.Ambulatory Care Research Facility and Clinical Center Modernization ACRF construction continued on schedule and within budget. The PDS also develops, formulates, and assays many investi- gational drug products used by physicians in their clinical research studies.Proposals for a cyclotron and the establishment of an Intraoperative Radiotherapy program were also considered. The Office of the Chief provides overall policy and direction to the services and centralized procurement of approximately ,000,000 worth of drugs and sterile supplies. DEPARTMENT ACTIVITIES As seen in Table I, unit doses dispensed increased from 594,753 to 723,108 (22%), sterile items compounded by the Intravenous Additive Unit (IVAU) decreased from 5,711 to 3,918 (32%), outpatient prescriptions dispensed decreased from 83,451 to 77,945 (7%), and IV admixtures prepared decreased from 163,978 to 151,158 (8%).During the fiscal year a number of construction projects were completed or begun. The entire pharmacy office, along with secretarial staff, was relocated to the South Corridor area outside of the main pharmacy in Room 1S-257.

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