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Networks of epithelial and endothelial tubes are essential for the function of organs such as the lung, kidney and vascular system. N.), an Achievement Rewards for College Scientists (ARCS) Award (to K. N.), a grant from the Northwestern University Alumni Association (to G. B.), NIH grant P50 GM 071508, principal investigator D.

The sizes and shapes of these tubes are highly regulated to match their individual functions.

Surprisingly, Src42 acts distinctly from known tube-size pathways and regulates both the amount of apical surface growth and, with the conserved formin d Daam, the direction of growth. Dudley for discussions, Bill Russin and the Northwestern Biological Imaging Facility for imaging support, S.

Quantitative three-dimensional image analysis reveals that Src42- and d Daam-mutant tracheal cells expand more in the circumferential than the axial dimension, resulting in tubes that are shorter in length—but larger in diameter—than wild-type tubes. Lammert for sharing unpublished results and comments on the manuscript, R.

‘It’s always tempting to ‘accidentally’ check out a date’s social media accounts before meeting up.

In fact, our research shows that over a third (38%) of us admit to a pre-date Google. In-depth social media stalking will make you form judgments before you’ve even sat down together so prioritise getting to know the real person, rather than their online persona.’ ‘A first date is your opportunity to get to know your date – and for them to get to know you.

It is therefore critical to understand how tube dimensions are regulated.

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